LY-294002 hydrochloride

CAS No. 934389-88-5

LY-294002 hydrochloride( —— )

Catalog No. M19270 CAS No. 934389-88-5

LY294002 is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 45 In Stock
5MG 61 In Stock
10MG 88 In Stock
25MG 161 In Stock
50MG 268 In Stock
100MG 424 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    LY-294002 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    LY294002 is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation.
  • Description
    LY294002 is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation.
  • In Vitro
    LY294002 hydrochloride (0-75 μM; 24 hours and 48 hours) remarkably decreases human nasopharyngeal carcinoma CNE-2Z cells in a dose-dependent fashion.LY294002 hydrochloride (0-75 μM; 24 hours and 48 hours ) induces CNE-2Z cells apoptosis rate in dose-dependent.LY294002 hydrochloride (10-75 μM) significantly decreases p-Akt (S473) expression levels and up-regulates caspase-9 activity in CNE-2Z cells. Total Akt protein level is not difference with different concentration.LY294002 hydrochloride (5, 10, 100 μM; for 2 hours) treatment partially suppresses Lysophosphatidic acid (LPA)-induced (20 μM; for 4 hours) nuclear translocation of YAP, accompanied by a reduction in p-AKT levels. Cell Proliferation Assay Cell Line:CNE-2Z cells Concentration:0 μM, 10 μM, 25 μM, 50 μM, and 75 μM Incubation Time:24 hours and 48 hours Result:Decreased CNE-2Z cells in a dose-dependent fashion.Apoptosis Analysis Cell Line:CNE-2Z cells Concentration:0 μM, 10 μM, 25 μM, 50 μM, and 75 μM Incubation Time:24 hours and 48 hours Result:Induced apoptosis rate in a dose-dependent manner. Western Blot Analysis Cell Line:CNE-2Z cells Concentration:0 μM, 10 μM, 25 μM, 50 μM, and 75 μM incubation Time:24 hours and 48 hours Result:Decreased phosphorylated Akt (S473) expression levels were significantly, up-regulated caspase-9 activity in CNE-2Z cells in treated group.
  • In Vivo
    LY294002 hydrochloride (10, 25, 50, 75 mg/kg; i.p.; twice weekly; for 4 weeks) significantly reduces mean NPC tumor burden in a dose-dependent manner. LY294002 (10, 25 mg/kg) is less effective in decreasing tumor burden. LY294002 hydrochloride (1.2 mg/kg per day; i.p.; for 14 days) prevents Leptin (60 ug/kg)-induced adverse effects on spermatozoa in Sprague-Dawley rats. Animal Model:Athymic nude mice (6-8 weeks) with CNE-2Z xenograft Dosage:10 mg/kg, 25 mg/kg, 50 mg/kg, and 75 mg/kg Administration:IP; twice weekly, for 4 weeks Result:Mean Nasopharyngeal carcinoma (NPC) tumor burden was remarkably decreased in a dose-dependent manner.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    p110α| p110β| p110δ
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    934389-88-5
  • Formula Weight
    343.81
  • Molecular Formula
    C19H17NO3·HCl
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chaussade C, et al. Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J. 2007 Jun 15;404(3):449-58.
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