![](../../files/images/goods/934389-88-5.png)
LY-294002 hydrochloride
CAS No. 934389-88-5
LY-294002 hydrochloride( —— )
Catalog No. M19270 CAS No. 934389-88-5
LY294002 is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation.
Purity : >98% (HPLC)
![](/themes/theme/en/images/pdf.png)
![](/themes/theme/en/images/pdf.png)
![](/themes/theme/en/images/pdf.png)
![](/themes/theme/en/images/pdf.png)
![](/themes/theme/en/images/pdf.png)
![](/themes/theme/en/images/pdf.png)
Size | Price / USD | Stock | Quantity |
2MG | 45 | In Stock |
![]() ![]() |
5MG | 61 | In Stock |
![]() ![]() |
10MG | 88 | In Stock |
![]() ![]() |
25MG | 161 | In Stock |
![]() ![]() |
50MG | 268 | In Stock |
![]() ![]() |
100MG | 424 | In Stock |
![]() ![]() |
200MG | Get Quote | In Stock |
![]() ![]() |
500MG | Get Quote | In Stock |
![]() ![]() |
1G | Get Quote | In Stock |
![]() ![]() |
Biological Information
-
Product NameLY-294002 hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionLY294002 is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation.
-
DescriptionLY294002 is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation.
-
In VitroLY294002 hydrochloride (0-75 μM; 24 hours and 48 hours) remarkably decreases human nasopharyngeal carcinoma CNE-2Z cells in a dose-dependent fashion.LY294002 hydrochloride (0-75 μM; 24 hours and 48 hours ) induces CNE-2Z cells apoptosis rate in dose-dependent.LY294002 hydrochloride (10-75 μM) significantly decreases p-Akt (S473) expression levels and up-regulates caspase-9 activity in CNE-2Z cells. Total Akt protein level is not difference with different concentration.LY294002 hydrochloride (5, 10, 100 μM; for 2 hours) treatment partially suppresses Lysophosphatidic acid (LPA)-induced (20 μM; for 4 hours) nuclear translocation of YAP, accompanied by a reduction in p-AKT levels. Cell Proliferation Assay Cell Line:CNE-2Z cells Concentration:0 μM, 10 μM, 25 μM, 50 μM, and 75 μM Incubation Time:24 hours and 48 hours Result:Decreased CNE-2Z cells in a dose-dependent fashion.Apoptosis Analysis Cell Line:CNE-2Z cells Concentration:0 μM, 10 μM, 25 μM, 50 μM, and 75 μM Incubation Time:24 hours and 48 hours Result:Induced apoptosis rate in a dose-dependent manner. Western Blot Analysis Cell Line:CNE-2Z cells Concentration:0 μM, 10 μM, 25 μM, 50 μM, and 75 μM incubation Time:24 hours and 48 hours Result:Decreased phosphorylated Akt (S473) expression levels were significantly, up-regulated caspase-9 activity in CNE-2Z cells in treated group.
-
In VivoLY294002 hydrochloride (10, 25, 50, 75 mg/kg; i.p.; twice weekly; for 4 weeks) significantly reduces mean NPC tumor burden in a dose-dependent manner. LY294002 (10, 25 mg/kg) is less effective in decreasing tumor burden. LY294002 hydrochloride (1.2 mg/kg per day; i.p.; for 14 days) prevents Leptin (60 ug/kg)-induced adverse effects on spermatozoa in Sprague-Dawley rats. Animal Model:Athymic nude mice (6-8 weeks) with CNE-2Z xenograft Dosage:10 mg/kg, 25 mg/kg, 50 mg/kg, and 75 mg/kg Administration:IP; twice weekly, for 4 weeks Result:Mean Nasopharyngeal carcinoma (NPC) tumor burden was remarkably decreased in a dose-dependent manner.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
Recptorp110α| p110β| p110δ
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number934389-88-5
-
Formula Weight343.81
-
Molecular FormulaC19H17NO3·HCl
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4.Cl
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Chaussade C, et al. Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J. 2007 Jun 15;404(3):449-58.
molnova catalog
![](/themes/theme/en/images/ct.png)
![](/themes/theme/en/images/new12.jpg)
![](/themes/theme/en/images/ct2.png)
related products
-
Methyl isovanillate
Methyl isovanillate is a natural product from Vitex agnus-castus.
-
Dihydroxyfumaric aci...
Dihydroxyfumaric acid is a known generator of superoxide anions and by hydroxyl free radicals. Dihydroxyfumarate exposure can cause insulin inhibitory effects. It can spontaneously convert to hydroxypyruvate or to oxaloglycolate.
-
Fmoc-N-Me-Ala-OH
Fmoc-N-Me-Ala-OH, an N-Fmoc-N-methyl amino acid, is available for the peptide-coupling reaction.